Healthcare
Academic
October 2025
npj Digital Medicine — Mass General Brigham

Three of five frontier models complied with illogical medical drug-equivalence requests 100% of the time.

“LLMs exhibit a tendency to comply with illogical requests that would generate false information, even when they have the knowledge to identify the request as illogical.”

100%
Compliance
(GPT-4 family)
94%
Compliance
(Llama-3-8B)
5
Frontier
models tested
How AVAAS solves this

Sycophancy in safety-critical domains is a deployment-blocking failure. Models that prioritize agreement over factual integrity do not pass clinical-deployment certification.

✓ Verified
Chen et al. (2025). npj Digital Medicine, 8, 605. nature.com

This entry is one of 37 documented cases in the AVAAS evidence ledger, a public record of AI and automated-system failures with a verified source on every entry.

Every case here reached a person.

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